MS Contin is the brand name for the generic compound Morphine sulphate, which is a potent opioid pain killer used to relive moderate to severe pain conditions. It was first used medicinally as an analgesic, and erroneously as a cure for opium addiction. The history of MS Contin is explained below.
Morphine was discovered in December 1804 as the first alkaloid that is extracted from the opium plant in Paderborn by the scientist Friedrich Serturner. Then it was marketed in 1817 by Serturner and company as a pain killer, and also for the treatment of opioid addiction. It was first sold commercially by Merck in the year 1827, which was a small chemist shop at that time. Morphine took its name from the Greek god, Morpheus.
It was then found that Morphine is more addictive when compared to opium or alcohol, and its expensive use in the American civil war led many soldiers suffer from morphine addiction or otherwise also known as "Soldiers disease" in that period. The phrase "Soldiers disease" was first documented during the period 1915, and there was much controversy about the fact that the existence of such disease was a fabrication and not real.
In the year 1906, the Pure Food and Drug act required accurate labelling for all patented tonics and medications. Thus various laws were enacted in US regarding the restriction on importation of opium. Thus it became a controlled substance in the year 1914 under the Harrison narcotic drug in US. This makes possession of morphine without a prescription as illegal or criminal offence in US. Despite legal laws, Morphine still maintained its popularity until heroin was discovered and came in to use. Heroin is nothing but DiacetylMorphine that is synthesised from morphine but has higher potency than Morphine. Heroin was believed to be the best cure for Morphine addiction,
During the year 1925, the structural formula for Morphine was discovered. Later Dr. Marshall D Gates, in the year 1952 patented and announced his process of synthesizing and developing Morphine from petroleum products. But still, the vast majority of Morphine is been synthesized from opium poppy seeds by either the traditional method of gathering the latex from the scored, processes using poppy straw, or unripe pods of the poppy. The stem and unripe pods of the poppy plant are the most wide spread method of used for synthesizing Morphine, which was invented in the year 1925 in Hungary and then announced by the researcher Janos kabay in the year 1930.
In the year 2003, Endogenous Morphine was discovered to be naturally found inside the human body. It took around 30 years to find the presence of endogenous morphine in human subjects. The receptor, mu3 opiate receptor in human tissues is known to react only to morphine. It has been discovered that trace amounts of endogenous Morphine can be found in in human cells that occurs as a reult of reaction to cancerous neuroblastoma cells.
Morphine is considered the most abundantly present alkaloid in opium. it obtained from the dried latex by shallowly slicing the dried pods of poppy. In the year 1874, heroin (Diacetylmorphine) was synthesized and brought to the market in the year 1898 by Bayer. It is more potent than Morphine, approximately 1.5 to 2 percentage. The higher potency of DiacetylMorphine is due to its lipid soluble activity, with which it can cross the blood brain barrier effectively and easily compared to morphine thereby increasing the reinforcing component of addiction.
Morphine is the most widely abused substance until Heroin was discovered. It is also true that until the synthesis of Oxycodone, Dihydro Morphine, Dihydromorphinone class of opioids, and other synthetic opioids, there were no drugs in the safe potency of Morphine and heroin in the market. The scarcity of heroin makes most addicts to look for Morphine, even today to get "high".
MS Contin contains the generic drug Morphine Sulphate, which was used as a potent pain killer when discovered. Later, the potent addictive effects of Morphine came in to light thus leading to the development of legislative acts to control its use without a prescription. It is one of the most widely used substance of abuse even today, next to heroin. The non-availability of heroin makes abusers look for this prescription narcotic, Morphine as a substances of abuse, which is obtained easily compared to Heroin.