Tylox Side Effects That Everyone Should Know

Tylox is a combination drug containing Oxycodone Hydrochloride and Acetaminophen and used in the treatment of moderate to severe pain. Oxycodone Hydrochloride is a narcotic pain reliever which acts on the brain to change the way how the body feels and relieves pain. Acetaminophen is a NSAID (non-steroidal anti-inflammatory drug) which is commonly used on the treatment of mild to moderate pain conditions.

Tylox side effects:

As with any medication, Tylox side effects can also occur in individuals taking it. However, not everyone who takes this drug will have side effects. The fact is that, most people tolerate Tylox quite well, and when side effects do occur they might be mild or can be easily treated by the health care provider. The various side effects of Tylox includes

1. Gastrointestinal side effects:

Common gastrointestinal side effects of Tylox includes nausea, vomiting, loss of appetite, upset stomach, dry mouth, constipation, and severe stomach or abdominal pain. To prevent symptoms of nausea and vomiting, it is advisable to take the medication with food. Symptoms of constipation can be avoided by taking this medication with plenty of water and including a fiber rich food in the diet. Stool softeners or stimulants can also be taken.

Gastrointestinal side effects occur commonly due to Oxycodone, not acetaminophen. But, when overdosed or taken with alcohol, acetaminophen may cause gastrointestinal side effects in patients.

2. Dermatologic side effects:

Acetaminophen may cause erythematous skin rashes, purpura fulminans, and bullous erythema, but these skin conditions are reported very rarely. Oxycodone may cause pruritis.

3. Nervous system side effect:

Oxycodone acts directly on the brain casing nervous system side effects which include dizziness, drowsiness, lightneadedness, sedation, convulsions, confusions, unusual behaviors or thoughts, euphoria, and dysphoria. Cases of respiratory depression have also been reported with Tylox usage. Conditions of respiratory depression are so severe that requires medical treatment immediately. Opioid antagonist, Naloxone is used to treat Tylox induced respiratory depression.

4. Hepatic side effects:

Hepatic side effects of Tylox may enhance with the use of thyroid drugs, alcohol, fasting, and zidovudine. Hepatic side effects include hepatotoxicity, and hepatic dysfunction. Hepatic dysfunction caused by drug overdose may sometimes be fatal, a requires medical attention immediately.

5. Allergic reactions:

Allergic reactions due to Tylox use are uncommon. Symptoms of fixed drug eruptions and anaphylaxis are very rarely reported with acetaminophen usage. Opioids like Oxycodone can cause histamine release in the body, and as a result can create itching sensations. Though, it is not an allergic reaction, it should be reported to the health care provided and get treated promptly.

6. Cardiovascular side effects:

Cardiovascular side effects caused by Tylox are very rare. Some side effects that ae reported includes slow heartbeat, and shallow breathing. Though these side effects are reported very rare, they are very serious enough to get medical treatment immediately.

7. Respiratory side effects:

Eosinophilic pneumonia has been reported with acetaminophen usage.

8. Hematologic side effects:

Side effects of Tylox in the Hematologic system are very rare. However, acute thrombocytopenia is reported with acetaminophen use. Overdose of acetaminophen may also cause Methemoglobinemia with resulting cyanosis.

9. Renal side effects:

Renal side effects are very rare with acetaminophen use, and include interstitial necrosis and acute tubular necrosis. Chronic acetaminophen abuse (that often happens with multiple analgesics) or acetaminophen related hepatotoxicity may cause additional renal effects on the body. Acute tubular necrosis caused by acetaminophen usually occurs in conjunction with liver failure, although identified very rare. The risk of renal cell carcinoma also increases with chronic acetaminophen use.

10. Metabolic side effects:

Massive overdose of Tylox can cause metabolic acidosis. In such cases, casualty is uncertain as more than one drug is often involved.

11. Other side effects:

Habit forming often occurs with Oxycodone use. It is an opioid analgesic and may cause withdrawal symptoms when stopped immediately. Withdrawal symptoms include restlessness, anxiety, agitation, tremor, insomnia, sweating, vomiting, blurred vision, piloerection, and abdominal cramps. These withdrawal symptoms can be minimized by slowly reducing the dose of the medication which can be done after consulting the health care provider.

Acetaminophen is often well tolerated in therapeutic dosage, though overdose can create many unwanted side effects in the body, which was discussed earlier.


Tylox works effectively as a pain killer due to the combination of 2 different medications that works in conjunction with each other. Tylox side effects are often reported in individuals, since both Oxycodone and Acetaminophen have its own side effects. This makes it important that individuals should be aware of these side effects before taking it. Also, as long as safety precautions are taken promptly, the use of Tylox is considered safe in most people.